That’s what Joseph Tirella wonders in a recent article for MSN Money.

Although only a small percentage of the overall beer market in the U.S., craft beers have grown in sales dollars by almost 60% since 2004. Beer from the “big” brewers is essentially flat, if not contracting.

Will microbrews kill the King of Beers?

The shift in consumer tastes — along with a commodities boom that has put pressure on profits throughout the beer industry — has put the jumbo players on the defensive. The industry’s No. 2 and 3 players, SABMiller and Molson Coors, respectively, are merging their operations in the U.S. and Puerto Rico. Their new company – MillerCoors – is expected to go into effect in July and will have a combined market share of nearly 30%.

And the nation’s self-titled King of Beers, Anheuser-Busch, has been dogged by the possible takeover by Belgian global powerhouse InBev.